ABC00120QD

Atenlol Imp F

Atenlol Imp F is a structurally related impurity derived from Atenolol, characterized by an additional hydroxyl group appended to the meta-position of the benzene ring and a truncated side chain lacking the terminal amine. This compound retains the core sulfonamide functionality and catechol moiety of the parent drug but exhibits altered steric hindrance due to the meta-hydroxyl substitution, which influences its metabolic stability and chromatographic behavior. Synthetically, it arises as a byproduct during oxidative coupling steps in Atenolol production. This impurity serves as a critical HPLC reference standard for quantifying process-related deviations in Atenolol API batches.

On Request
Molecular Formula C25H35N3O6
Molecular Weight 473.6000
CAS Number 87619-83-8 ⚠ Unverified
PubChem CID 624265 ↗
Purity N/A
Product Type API Impurity
Parent Drug Atenolol
Lead Time On Request
IUPAC Name 2-[4-[3-[[3-[4-(2-amino-2-oxoethyl)phenoxy]-2-hydroxypropyl]-propan-2-ylamino]-2-hydroxypropoxy]phenyl]acetamide
Official Reference Standards
Std Catalog # Quantity Price
USP 1044367 ↗ 25 mg USD 823.00

📝 Synonyms

Atenolol impurity D Atenolol impurity F N-Des(isopropyl)atenolol dimer 8UO8372UKO Atenolol impurity F [EP] UNII-8UO8372UKO 2-[4-[3-[[3-[4-(2-amino-2-oxoethyl)phenoxy]-2-hydroxypropyl]-propan-2-ylamino]-2-hydroxypropoxy]phenyl]acetamide ATENOLOL IMPURITY F [EP IMPURITY] 2,2-(((Propan-2-yl)azanediyl)bis((2-hydroxypropane-3,1-diyl)oxy-4,1-phenylene))diacetamide 4,4'-(((1-Methylethyl)imino)bis((2-hydroxy-3,1-propanediyl)oxy))bis-benzeneacetamide

🔬 Chemical Identifiers

CC(C)N(CC(COC1=CC=C(C=C1)CC(=O)N)O)CC(COC2=CC=C(C=C2)CC(=O)N)O
InChI=1S/C25H35N3O6/c1-17(2)28(13-20(29)15-33-22-7-3-18(4-8-22)11-24(26)31)14-21(30)16-34-23-9-5-19(6-10-23)12-25(27)32/h3-10,17,20-21,29-30H,11-16H2,1-2H3,(H2,26,31)(H2,27,32)
SYUQLMYOHVGLTC-UHFFFAOYSA-N

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