Atorvastatin 2-Fluoro Analog

Atorvastatin 2-Fluoro Analog (CAS 1346746-49-3) is a fluorinated derivative of Atorvastatin, characterized by a 2-fluoro substitution on the pyrrole ring. This modification introduces a stereoelectronically distinct fluorine atom, disrupting the parent compound's hydrogen-bonding network while preserving the lactone hydrolase-sensitive ester and polar hydroxy group. The fluorine substitution enhances metabolic stability in synthetic intermediates, arising as a process impurity during selective fluorination steps. This compound functions as an HPLC reference standard for quantifying fluorination-related impurities in Atorvastatin API synthesis.