ABC00229BF

Atorvastatin Impurity-F sodium salt(amide impurity)

Atorvastatin Impurity-F sodium salt is an amide-derived byproduct formed during the synthesis of Atorvastatin, characterized by a sodium counterion associated with a deprotonated carboxylic acid moiety. The compound retains the core HMG-CoA reductase inhibitor scaffold of Atorvastatin but features an amide linkage replacing a critical ester functionality in the parent molecule. This structural substitution alters its hydrolytic stability and chromatographic behavior, necessitating its quantification as a process-related impurity. The sodium salt form enhances solubility for analytical applications. It serves as a reference standard for HPLC-based impurity profiling in Atorvastatin drug substance characterization.

On Request
Molecular Formula C40H47FN3NaO8
Molecular Weight 739.8000
CAS Number 1371615-56-3 ✓ Verified
PubChem CID 165723790 ↗
Purity N/A
Product Type API Impurity
Parent Drug Atorvastatin
Lead Time On Request
IUPAC Name sodium (3R,5R)-7-[[(3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoyl]amino]-3,5-dihydroxyheptanoate

📝 Synonyms

Atorvastatin IMpurity F 1371615-56-3 sodium (3R,5R)-7-[(3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanamido]-3,5-dihydroxyheptanoate Sodium (3R,5R)-7-((3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanamido)-3,5-dihydroxyheptanoate Atorvastatin N-(3,5-Dihydroxy-7-heptanoic Acid)amide Sodium Salt DTXSID201356765 Atorvastatin EP Impurity F(Sodium Salt) FA165540 EN300-7431490 (3R,5R)-7-[[(3R,5R)-7-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-3,5-dihydroxy-1-oxoheptyl]amino]-3,5-dihydroxyheptanoic Acid Sodium Salt (1:1)

🔬 Chemical Identifiers

CC(C)C1=C(C(=C(N1CC[C@H](C[C@H](CC(=O)NCC[C@H](C[C@H](CC(=O)[O-])O)O)O)O)C2=CC=C(C=C2)F)C3=CC=CC=C3)C(=O)NC4=CC=CC=C4.[Na+]
InChI=1S/C40H48FN3O8.Na/c1-25(2)38-37(40(52)43-29-11-7-4-8-12-29)36(26-9-5-3-6-10-26)39(27-13-15-28(41)16-14-27)44(38)20-18-31(46)22-32(47)23-34(49)42-19-17-30(45)21-33(48)24-35(50)51;/h3-16,25,30-33,45-48H,17-24H2,1-2H3,(H,42,49)(H,43,52)(H,50,51);/q;+1/p-1/t30-,31-,32-,33-;/m1./s1
OHFKZDUXUWJNCG-ZNOPIPGTSA-M

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