ABC00239NL

Atorvastatin Pyrrolidone Analog

Atorvastatin Pyrrolidone Analog is a fluorinated, pyrrolidone-containing derivative structurally related to Atorvastatin. It features a substituted pyrrole fused to a pyrrolidone ring, with an ester-linked phenylpropanoic acid moiety and a fluorinated aryl group. The compound diverges from the parent drug by replacing the lactone with a cyclic amide (pyrrolidone) and incorporating an additional amide linkage. This analog arises as a synthetic byproduct during Atorvastatin API production, specifically during pyrrole ring formation. Its structural stability and chromatographic properties make it a critical reference standard for HPLC-based impurity profiling in quality control processes.

On Request
Molecular Formula C33H34FN2NaO6
Molecular Weight 596.6000
CAS Number 148217-40-7 ✓ Verified
PubChem CID 71313455 ↗
Purity N/A
Product Type API Impurity
Parent Drug Atorvastatin
Lead Time On Request
IUPAC Name sodium (3R,5R)-7-[5-(4-fluorophenyl)-2-oxo-4-phenyl-3-(phenylcarbamoyl)-3-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoate
Official Reference Standards
Std Catalog # Quantity Price
USP 1A00810 ↗ 25 mg USD 3000.00

📝 Synonyms

Atorvastatin Lactam Sodium Salt Impurity 148217-40-7 sodium;(3R,5R)-7-[5-(4-fluorophenyl)-2-oxo-4-phenyl-3-(phenylcarbamoyl)-3-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoate C33H34FN2NaO6 DTXSID40747048 IA18018 (b-R,?R)-5-(4-Fluorophenyl)-2,3-dihydro-b,?-dihydroxy-3-(1-methylethyl)-2-oxo-4-phenyl-3-[(phenylamino)carbonyl]-1H-pyrrole-1-heptan oic acid sodium salt Sodium (3R,5R)-7-[5-(4-fluorophenyl)-2-oxo-4-phenyl-3-(phenylcarbamoyl)-3-(propan-2-yl)-2,3-dihydro-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate sodium;(3R,5R)-7-[5-(4-fluorophenyl)-3-isopropyl-2-oxo-4-phenyl-3-(phenylcarbamoyl)pyrrol-1-yl]-3,5-dihydroxy-heptanoate

🔬 Chemical Identifiers

CC(C)C1(C(=C(N(C1=O)CC[C@H](C[C@H](CC(=O)[O-])O)O)C2=CC=C(C=C2)F)C3=CC=CC=C3)C(=O)NC4=CC=CC=C4.[Na+]
InChI=1S/C33H35FN2O6.Na/c1-21(2)33(31(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)30(23-13-15-24(34)16-14-23)36(32(33)42)18-17-26(37)19-27(38)20-28(39)40;/h3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40);/q;+1/p-1/t26-,27-,33?;/m1./s1
AWDUSRYVYMXRPW-LGZZEMPASA-M

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