ABC00236YD

Atorvastatin related compound H

Atorvastatin related compound H is a dimeric byproduct arising from the coupling of two Atorvastatin moieties via a methylene bridge, featuring a fluorophenyl substituent, a pyrrole-fused tetrahydrofuran ring, and a hydroxylated lactone core. Its structure retains key pharmacophoric elements of the parent drug but exhibits altered stereochemistry and an additional ester linkage. This impurity is formed during synthetic over-coupling in the final API synthesis step. Serves as an HPLC reference standard for quantifying process-related impurities in Atorvastatin formulations.

On Request
Molecular Formula C33H33FN2O4
Molecular Weight 540.6000
CAS Number 125995-03-1 ✓ Verified
PubChem CID 6483036 ↗
Purity N/A
Product Type API Impurity
Parent Drug Atorvastatin
Lead Time On Request
IUPAC Name 5-(4-fluorophenyl)-1-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-N,4-diphenyl-2-propan-2-ylpyrrole-3-carboxamide
Official Reference Standards
Std Catalog # Quantity Price
USP 1044582 ↗ 20 mg USD 880.00

📝 Synonyms

Atorvastatin lactone 125995-03-1 Atorvastatin delta-Lactone UNII-7876IL7J2N 1H-Pyrrole-3-carboxamide, 5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]- 7876IL7J2N DTXSID90155033 1H-Pyrrole-3-carboxamide, 5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-(2-((2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)- 1H-PYRROLE-3-CARBOXAMIDE, 5-(4-FLUOROPHENYL)-2-(1-METHYLETHYL)-N,4-DIPHENYL-1-(2-(TETRAHYDRO-4-HYDROXY-6-OXO-2H-PYRAN-2-YL)ETHYL)-, (2R-TRANS)- 1H-Pyrrole-3-carboxamide, 5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-, (2R-trans)-

🔬 Chemical Identifiers

CC(C)C1=C(C(=C(N1CC[C@@H]2C[C@H](CC(=O)O2)O)C3=CC=C(C=C3)F)C4=CC=CC=C4)C(=O)NC5=CC=CC=C5
InChI=1S/C33H33FN2O4/c1-21(2)31-30(33(39)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-27-19-26(37)20-28(38)40-27/h3-16,21,26-27,37H,17-20H2,1-2H3,(H,35,39)/t26-,27-/m1/s1
OUCSEDFVYPBLLF-KAYWLYCHSA-N

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