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betamethasone-17-benzoate

Betamethasone-17-benzoate is a synthetic corticosteroid derivative featuring a pregnane backbone with a 17ฮฑ-hydroxy group esterified to benzoic acid, forming an aromatic ester linkage. The molecule retains the 11ฮฒ,17ฮฑ-dihydroxy-3-oxo-ฮ”โด-pregnadiene core of betamethasone but substitutes the 17ฮฒ-acetate side chain with a benzoate moiety. This structural modification alters its lipophilicity and metabolic stability, positioning it as a synthetic byproduct during API synthesis. It serves as an HPLC reference standard for quantifying esterification pathway impurities in corticosteroid formulations.

On Request
Molecular Formula C29H33FO6
Molecular Weight 496.6000
CAS Number 22298-29-9 โœ“ Verified
PubChem CID 5282492 โ†—
Purity N/A
Product Type API Impurity
Parent Drug Betamethasone
Lead Time On Request
IUPAC Name [(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] benzoate
Official Reference Standards
Std Catalog # Quantity Price
USP 1067307 โ†— 200 mg USD 282.00

๐Ÿ“ Synonyms

BETAMETHASONE BENZOATE Betamethasone 17-benzoate 22298-29-9 Uticort W 5975 W-5975 DTXSID2022670 877K0XW47A Pregna-1,4-diene-3,20-dione, 17-(benzoyloxy)-9-fluoro-11,21-dihydroxy-16-methyl-, (11beta,16beta)- RefChem:54525

๐Ÿ”ฌ Chemical Identifiers

C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)OC(=O)C5=CC=CC=C5)C)O)F)C
InChI=1S/C29H33FO6/c1-17-13-22-21-10-9-19-14-20(32)11-12-26(19,2)28(21,30)23(33)15-27(22,3)29(17,24(34)16-31)36-25(35)18-7-5-4-6-8-18/h4-8,11-12,14,17,21-23,31,33H,9-10,13,15-16H2,1-3H3/t17-,21-,22-,23-,26-,27-,28-,29-/m0/s1
SOQJPQZCPBDOMF-YCUXZELOSA-N

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