ABC00282IC

Betamethasone-21-acetate-17-Propionate

Betamethasone-21-acetate-17-propionate is a corticosteroid derivative featuring esterification of the 21-hydroxyl group with acetic acid and the 17ฮฑ-hydroxyl group with propionic acid. This dual esterification modifies the parent drug's solubility and metabolic profile by introducing branched aliphatic ester moieties, enhancing lipophilicity while retaining the core 4-pregnene-3,20-dione scaffold. The compound arises as a synthetic intermediate in the esterification pathway of betamethasone, utilized as an HPLC reference standard for quantifying esterification efficiency in API production.

On Request
Molecular Formula C27H35FO7
Molecular Weight 490.6000
CAS Number 5514-81-8 โœ“ Verified
PubChem CID 70270274 โ†—
Purity N/A
Product Type API Impurity
Parent Drug Betamethasone
Lead Time On Request
IUPAC Name [(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-acetyloxyacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate

๐Ÿ“ Synonyms

[(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-acetyloxyacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate ((8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-acetyloxyacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta(a)phenanthren-17-yl) propanoate RefChem:390343 891-970-1 Betamethasone 21-Acetate 17-Propionate 5514-81-8 UNII-WZ44Y19OXW Betamethasone dipropionate impurity D WZ44Y19OXW Betamethasone 21-acetate-17-propionate

๐Ÿ”ฌ Chemical Identifiers

CCC(=O)O[C@@]1([C@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2CCC4=CC(=O)C=C[C@@]43C)F)O)C)C)C(=O)COC(=O)C
InChI=1S/C27H35FO7/c1-6-23(33)35-27(22(32)14-34-16(3)29)15(2)11-20-19-8-7-17-12-18(30)9-10-24(17,4)26(19,28)21(31)13-25(20,27)5/h9-10,12,15,19-21,31H,6-8,11,13-14H2,1-5H3/t15-,19-,20-,21-,24-,25-,26-,27-/m0/s1
KJYZDNSUFNSFOL-JLWJLQCMSA-N

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