Blonanserin Dimer imp

Blonanserin Dimer imp is a dimeric impurity derived from the antipsychotic parent compound Blonanserin, formed via coupling of two benzisothiazole-piperazine moieties through a covalent linkage between the piperazine nitrogen and an aromatic carbon. This structural dimerization introduces increased molecular rigidity and altered electronic properties compared to the monomeric drug. The dimer retains key pharmacophoric elements but exhibits distinct chromatographic and spectroscopic signatures. It serves as a critical HPLC reference standard for quantifying process-related impurities in Blonanserin bulk drug synthesis.