Canagliflozin Alpha and Beta Isomer

Canagliflozin Alpha and Beta Isomer is a stereoisomeric impurity arising from the pyranose ring configuration in the parent drug Canagliflozin. The isomers differ in the spatial orientation of the hydroxyl group at the C-1 position, leading to distinct anomeric configurations (α vs. β). Both isomers retain the core structure of Canagliflozin, including the 1-(4-chlorophenyl)-3-[(4-hydroxyphenyl)methyl]pyrazolidin-2-one scaffold and the 1,5-anhydro-1,4-dideoxy-D-ribo-hexitol moiety. These isomers are critical byproducts formed during asymmetric synthesis or racemic resolution processes. This compound serves as an HPLC reference standard for quantifying stereoisomeric impurities in Canagliflozin drug substance analysis.