Canagliflozin Dimer

Canagliflozin Dimer is a dimeric impurity derived from the antidiabetic drug Canagliflozin, formed via oxidative coupling of two parent molecules through their phthalimide moieties. The dimer exhibits a symmetrical bis(phthalimide) core linked by a methylene bridge, retaining the glucose-derived pharmacophore at each terminus. This structural configuration arises from synthetic pathway byproducts or photooxidative degradation under stressed conditions. The compound serves as a critical HPLC reference standard for quantifying process-related impurities in Canagliflozin drug substance analysis.