Canagliflozin impurity C

Canagliflozin impurity C is a brominated aromatic sulfide derivative featuring a substituted benzene ring with a fluorosulfanyl (–SF) group and a para-bromo substituent. Its structure incorporates a 4-fluoro-3-bromophenyl moiety linked to a methylsulfanyl group, diverging from the parent drug by the replacement of a methoxy group with bromine and fluorine substitutions. This impurity arises during synthetic oxidation steps involving sulfide intermediates. It serves as a critical HPLC reference standard for quantifying process-related impurities in canagliflozin formulations.