Canagliflozin impurity F

Canagliflozin impurity F is a structurally related degradation byproduct arising from oxidative cleavage of the parent drug's 5-hydroxymethyl group, resulting in a carboxylic acid functionality. It retains the core benzene-fused furanose-derived pyran ring system and 4-fluorophenyl substituent characteristic of canagliflozin but features a terminal carboxylic acid at the C5 position. This impurity forms under accelerated stress conditions, reflecting a specific oxidation pathway. It serves as a critical HPLC reference standard for quantifying oxidative degradation in stability studies of canagliflozin formulations.