Capecitabine Related Compound C

Capecitabine Related Compound C is a degradation byproduct arising from oxidative cleavage of the cyclopropylmethyl ester moiety in the parent prodrug, introducing a hydroxyl-substituted fluorouracil core conjugated to a dicarboxylic acid spacer. This impurity features an additional hydroxyl group at the terminal carbon of the propyl linker, disrupting the ester functionality critical for capecitabine's prodrug activation cascade. Structurally, it retains the 5-fluorouracil pharmacophore but exhibits altered solubility and chromatographic behavior due to enhanced hydrogen bonding capacity. Serves as a reference standard for HPLC-based quantification of oxidative degradation pathways in capecitabine formulations.