Cefuroxime Sodium EP Impurity E is a degradation byproduct arising from hydrolytic cleavage of the ฮฒ-lactam ring in the parent cephalosporin, retaining a thiazole moiety and a sodium-modified carboxylate terminus. Its structure features a fused oxepane-thiazole core with a truncated side chain compared to cefuroxime, bearing an acetylamino group at C-3 and a deprotonated carboxylic acid functionality. This impurity serves as a critical HPLC reference standard for quantifying process-related degradation in cefuroxime formulations.
On Request| Std | Catalog # | Quantity | Price |
|---|---|---|---|
| USP | 1A18270 โ | 25 mg | USD 918.00 |
CO/N=C(/C1=CC=CO1)\C(=O)N[C@H]2[C@@H]3N(C2=O)C4=C(COC4=O)CS3
InChI=1S/C15H13N3O6S/c1-22-17-9(8-3-2-4-23-8)12(19)16-10-13(20)18-11-7(5-24-15(11)21)6-25-14(10)18/h2-4,10,14H,5-6H2,1H3,(H,16,19)/b17-9-/t10-,14-/m1/s1
LRBGPGHWGUNCJM-FBCAJUAOSA-N