Ciprofloxacin EP Impurity-C (crude)

Ciprofloxacin EP Impurity-C (crude) is a fluoroquinolone-derived impurity characterized by a quinolone core bearing a 6-fluoro substitution, a piperazine ring at position 7, and a carboxylic acid moiety at position 3. It exhibits structural deficiency in the cyclopropyl group at position 1 compared to the parent drug, resulting in a truncated aliphatic chain. This compound arises as a synthetic byproduct during ciprofloxacin manufacturing via alkylation pathway deviations. Its primary application is as an HPLC reference standard for quantifying process-related impurity profiles in ciprofloxacin active pharmaceutical ingredient batches.