Clomipramine 13CD3 Hydrochloride Salt

Clomipramine 13CD3 Hydrochloride Salt is a deuterated analog of the tricyclic antidepressant clomipramine, featuring three deuterium atoms substituted at the aromatic ring's meta positions relative to the dimethylamino group. This isotopically labeled derivative retains the core tricyclic structure (1-phenyl-1,2,3,4-tetrahydroisoquinoline) and the terminal dimethylamino functionality, with deuterium enrichment at C-10, C-11, and C-12 positions. The hydrochloride salt formation occurs via protonation of the tertiary amine, yielding a crystalline solid. This compound serves as an HPLC reference standard for quantifying clomipramine-related impurities in pharmaceutical formulations.