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Clomipramine N-Oxide

Clomipramine N-Oxide is an oxidation derivative of the tricyclic antidepressant Clomipramine, featuring an N-oxide functional group at the piperidine nitrogen. Its structure retains the dibenzofuran core and methylethyl side chain of the parent compound, with an additional oxygen atom in a trigonal pyramidal geometry. This impurity arises via oxidative degradation pathways, commonly observed under stress conditions. It serves as a critical HPLC reference standard for quantifying oxidative impurities in Clomipramine formulations.

On Request
Molecular Formula C19H23ClN2O
Molecular Weight 330.8000
CAS Number 14171-67-6 ✓ Verified
PubChem CID 29976360 ↗
Purity N/A
Product Type API Impurity
Parent Drug Clomipramine
Lead Time On Request
IUPAC Name 3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine oxide

📝 Synonyms

14171-67-6 Chlorimipramine N-oxide N-Oxide chlorimipramine 2HU39OEA67 UNII-2HU39OEA67 3-(2-Chloro-5,6-dihydrobenzo(b)(1)benzazepin-11-yl)-N,N-dimethyl-propan-1-amine oxide 5H-Dibenz(b,f)azepine, 3-chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro-, N-oxide 3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethyl-propan-1-amine oxide RefChem:202202 Clomipramine N-Oxide

🔬 Chemical Identifiers

C[N+](C)(CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)Cl)[O-]
InChI=1S/C19H23ClN2O/c1-22(2,23)13-5-12-21-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)21/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3
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