Curcumin beta-D-Glucuronide (Crude)

Curcumin beta-D-Glucuronide is a Phase II metabolic conjugate formed via glucuronic acid linkage to a phenolic hydroxyl group of curcumin, featuring a beta-D-anomeric configuration at the glycosidic bond. The compound retains the bis-phenolic core of curcumin with an additional uronic acid moiety, introducing a carboxylic acid and multiple hydroxyl functionalities. This conjugation enhances water solubility relative to the parent compound, facilitating excretion. It serves as an HPLC reference standard for quantifying glucuronidation-derived impurities in curcumin-based pharmaceuticals.