ABC00444SM

Cyanocobalamin Impurity D

Cyanocobalamin Impurity D is a structurally related degradation byproduct arising from oxidative cleavage of the corrin macrocycle in Cyanocobalamin, featuring a substituted cobalt-coordinated tetrapyrrole core with a terminal nitrile group and a phosphorylated ribose moiety. This impurity exhibits a distinct substitution pattern at the 5-position of the corrin ring, resulting in altered redox stability and chromatographic behavior. It serves as a reference standard for HPLC-based quantification of process-related impurities in Cyanocobalamin formulations.

On Request
Molecular Formula C63H86CoN14O14P
Molecular Weight 1353.3000
CAS Number 23388-02-5 ✓ Verified
PubChem CID 178186391 ↗
Purity N/A
Product Type API Impurity
Parent Drug Cyanocobalamin
Lead Time On Request
IUPAC Name [(2R)-1-[3-[(1Z,4S,5S,6R,7R,8R,9R,10E,13S,15Z)-5,8-bis(2-amino-2-oxoethyl)-4,13,18-tris(3-amino-3-oxopropyl)-2,5,6,9,11,14,14,22-octamethyl-20-oxo-19,23,24,26-tetraza-25-azanidahexacyclo[15.5.1.13,6.17,10.112,15.018,22]hexacosa-1,3(26),10,12(24),15,17(23)-hexaen-9-yl]propanoylamino]propan-2-yl] [(2R,3S,4R,5S)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] phosphate;cobalt(3+);cyanide

📝 Synonyms

Vitamin B-12 C-Lactam (Technical Grade) 23388-02-5

🔬 Chemical Identifiers

CC1=CC2=C(C=C1C)N(C=N2)[C@@H]3[C@@H]([C@@H]([C@H](O3)CO)OP(=O)([O-])O[C@H](C)CNC(=O)CC[C@@]/4([C@H]([C@@H]5[C@]6([C@@]([C@@H](C(=N6)/C(=C\7/C8(CC(=O)NC8(C(=N7)/C=C\9/C([C@@H](C(=N9)/C(=C4/[N-]5)/C)CCC(=O)N)(C)C)CCC(=O)N)C)/C)CCC(=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.[C-]#N.[Co+3]
InChI=1S/C62H88N13O14P.CN.Co/c1-29-20-37-38(21-30(29)2)75(28-69-37)56-51(84)52(39(27-76)87-56)89-90(85,86)88-31(3)26-68-47(82)17-18-58(8)36(22-45(66)80)55-61(11)59(9,24-46(67)81)35(13-15-43(64)78)50(74-61)33(5)54-60(10)25-48(83)73-62(60,19-16-44(65)79)41(71-54)23-40-57(6,7)34(12-14-42(63)77)49(70-40)32(4)53(58)72-55;1-2;/h20-21,23,28,31,34-36,39,51-52,55-56,76,84H,12-19,22,24-27H2,1-11H3,(H14,63,64,65,66,67,68,70,71,72,73,74,77,78,79,80,81,82,83,85,86);;/q;-1;+3/p-2/t31-,34-,35-,36+,39-,51-,52-,55-,56+,58-,59+,60?,61+,62?;;/m1../s1
PQOCGDLYVXNQKQ-UHKGZVQOSA-L

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