daclatasvir enatiomer

Daclatasvir enantiomer is the non-pharmaceutical stereoisomer of the antiviral agent daclatasvir, characterized by inverted configuration at its two chiral centers (C-4 and C-5) within the tetrahydrofuran core. It retains the 2-amino-5-(2,6-dichlorophenyl)-7-(2-pyridinyl)-7H-pyrrolo[2,3-d]pyrimidin-4(5H)-one scaffold but exhibits opposite optical activity. This enantiomer lacks the parent drug’s NS5A inhibitory potency due to steric hindrance in the binding pocket. It serves as a chiral HPLC reference standard for enantiomeric purity analysis of daclatasvir APIs.