Dapagliflozin impurity 2

Dapagliflozin impurity 2 is a bromochlorinated aromatic derivative featuring a substituted benzene ring with ortho-oriented bromine and chlorine atoms, linked to a hydroxymethyl group and a pyran-2-one core. Its structure incorporates an ether bridge connecting the aromatic system to a cyclopropane moiety, mirroring the parent drug’s scaffold but with halogen substitution at critical positions. This impurity arises as a synthetic byproduct during bromination or chlorination steps in dapagliflozin manufacturing. It serves as an HPLC reference standard for quantifying this specific process-related impurity in quality control assays.