Dapagliflozin impurity 8

Dapagliflozin impurity 8 is a structurally related byproduct arising from the oxidative degradation of the parent compound’s pyran ring, featuring a ketone functionality at the C-4 position and retention of the benzene-derived hydroxyl group. This impurity exhibits a distinct electron-withdrawing character due to the carbonyl substitution, altering its polarity and chromatographic behavior compared to dapagliflozin. It serves as a critical HPLC reference standard for quantifying degradation pathways in stability studies of SGLT2 inhibitor formulations.