Dapagliflozin

Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor with a substituted benzodioxole core linked to a pyran ring via a methylene bridge. The molecule features a 4-chlorophenyl substituent and a hydroxylated piperidinyl moiety, conferring structural similarity to the parent drug Dapagliflozen. Key differentiating features include an oxidized pyran ring and a truncated side chain, resulting from synthetic pathway divergence during API production. This impurity arises via oxidative degradation of the parent compound under acidic conditions. It serves as an HPLC reference standard for quantifying process-related impurities in dapagliflozin formulations.