ABC00354MR

Deacetyl Cefotaxime lactone

Deacetyl Cefotaxime lactone is a cephalosporin-derived API impurity formed by deacetylation of Cefotaxime, featuring a beta-lactam fused to a dihydrothiazine core with a lactone ring in the side chain. The compound retains the 7-aminocephalosporanic acid scaffold but lacks the acetyl substituent, replacing it with a cyclic ester functionality. This structural modification alters its stability and chromatographic behavior compared to the parent antibiotic. It serves as an HPLC reference standard for quantifying process-related impurities in Cefotaxime formulations.

On Request
Molecular Formula C14H13N5O5S2
Molecular Weight 395.4000
CAS Number 66340-33-8 ✓ Verified
PubChem CID 13080558 ↗
Purity N/A
Product Type API Impurity
Parent Drug Cefotaxime
Lead Time On Request
IUPAC Name (2Z)-2-(2-amino-1,3-thiazol-4-yl)-N-[(4R,5R)-3,11-dioxo-10-oxa-6-thia-2-azatricyclo[6.3.0.02,5]undec-1(8)-en-4-yl]-2-methoxyiminoacetamide
Official Reference Standards
Std Catalog # Quantity Price
USP 1097953 ↗ 15 mg USD 996.00

📝 Synonyms

66340-33-8 Deacetylcefotaxime lactone Ceftriaxone impurity B Cefotaxime impurity E [EP] UNII-3Z40JM5X8L 3Z40JM5X8L Cefotaxime sodium impurity E [EP] Ceftriaxone sodium impurity B [EP] Cefotaxime specified impurity E [EP] DTXSID70216550

🔬 Chemical Identifiers

CO/N=C(/C1=CSC(=N1)N)\C(=O)N[C@H]2[C@@H]3N(C2=O)C4=C(COC4=O)CS3
InChI=1S/C14H13N5O5S2/c1-23-18-7(6-4-26-14(15)16-6)10(20)17-8-11(21)19-9-5(2-24-13(9)22)3-25-12(8)19/h4,8,12H,2-3H2,1H3,(H2,15,16)(H,17,20)/b18-7-/t8-,12-/m1/s1
MCSWUKXFFGUOQE-GHXIOONMSA-N

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