Dehydrolercanidipine

Dehydrolercanidipine is a structurally related impurity of lercanidipine, characterized by a substituted dihydropyridine core linked to a tricyclic aromatic system featuring a 1,4-dihydropyridine motif, a nitrobenzene moiety, and a cyclohexylmethyl ester group. The compound exhibits a dehydrated scaffold relative to the parent drug, with a specific loss of a hydroxyl functionality at the 4-position of the dihydropyridine ring, resulting in a conjugated double bond system. This structural modification alters its metabolic stability and chromatographic behavior. It serves as a critical HPLC reference standard for quantifying process-related impurities in lercanidipine active pharmaceutical ingredient synthesis.