Des Chloro Dapagliflozin

Des Chloro Dapagliflozin is a structurally related impurity of Dapagliflozin, characterized by the absence of the 4-chlorophenyl substituent on the benzene ring, replaced by a hydrogen atom. This compound retains the core scaffold of the parent drug, featuring a naphthalene-2-sulfonamide moiety linked to a 1,5-dihydroxy-1-methylpentyl side chain. The removal of the chloro group alters the electronic and steric properties, rendering it a critical process-related impurity in synthetic pathways involving chlorination steps. It serves as a reference standard for HPLC-based impurity profiling in Dapagliflozin bulk drug substance analysis.