Deschloro Sertaline

Deschloro Sertaline is a dechlorinated derivative of Sertraline, characterized by an indole-based scaffold fused to a para-substituted aromatic ring, with a primary amine group at the 3-position of the indole core. The absence of the chlorine atom present in Sertraline at the benzyl position distinguishes its electrophilic profile, while retaining the chiral center critical for pharmacological activity. This impurity arises via dechlorination pathways during synthesis or degradation. It serves as an HPLC reference standard for quantifying process-related impurities in Sertraline formulations.