Desfluoro Canagliflozin

Desfluoro Canagliflozin is a structurally related impurity of Canagliflozin, characterized by the absence of a 4-fluoro substituent on the phenyl ring of the parent compound. It retains the core sulfonamide-benzyl-fructofuranoside scaffold, featuring a 1,5-anhydro-1C-pentitol glycoside linked via a sulfur atom to a 4-chlorobenzoyl group. The removal of the fluorine atom alters the electronic distribution of the aromatic ring, potentially affecting metabolic stability. This compound arises as a synthetic byproduct during Canagliflozin production via defluorination pathways. It serves as a critical HPLC reference standard for quantifying process-related impurities in pharmaceutical development.