ABC00165UZ

Desmethyl Amlodipine

Desmethyl Amlodipine is a 1,4-dihydropyridine derivative featuring a chlorophenyl substituent and a nitro-substituted ethylamine side chain, characterized by demethylation at the pyridine nitrogen relative to Amlodipine. This structural modification eliminates the methyl group adjacent to the dihydropyridine ring, introducing an exocyclic amino functionality. As a synthetic byproduct arising during Amlodipine manufacturing, it serves as a critical HPLC reference standard for impurity profiling in quality control.

On Request
Molecular Formula C19H23ClN2O5
Molecular Weight 394.8000
CAS Number 113994-37-9 ✓ Verified
PubChem CID 14271883 ↗
Purity N/A
Product Type API Impurity
Parent Drug Amlodipine
Lead Time On Request
IUPAC Name 6-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-5-ethoxycarbonyl-2-methyl-1,4-dihydropyridine-3-carboxylic acid
Official Reference Standards
Std Catalog # Quantity Price
USP 1A10930 ↗ 25 mg USD 685.00

📝 Synonyms

Desmethyl amolodipine 113994-37-9 3-O-Desmethyl Amlodipine 6-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-5-ethoxycarbonyl-2-methyl-1,4-dihydropyridine-3-carboxylic acid 6-((2-Aminoethoxy)methyl)-4-(2-chlorophenyl)-5-(ethoxycarbonyl)-2-methyl-1,4-dihydropyridine-3-carboxylic acid 3-Ethyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate 6-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-5-(ethoxycarbonyl)-2-methyl-1,4-dihydropyridine-3-carboxylic acid Amlodipine Impurity 7 Desmethylamolodipine (M6) SCHEMBL28407480

🔬 Chemical Identifiers

CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)O)C)COCCN
InChI=1S/C19H23ClN2O5/c1-3-27-19(25)17-14(10-26-9-8-21)22-11(2)15(18(23)24)16(17)12-6-4-5-7-13(12)20/h4-7,16,22H,3,8-10,21H2,1-2H3,(H,23,24)
RMMLXNROVBYURX-UHFFFAOYSA-N

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