ABC00164NG

Di-acid Amlodipine

Di-acid Amlodipine is a dihydroxy-oxidized derivative of amlodipine, featuring two additional carboxylic acid groups introduced via oxidative cleavage of the pyridine ring side chain. This impurity retains the 1,4-dihydropyridine core and chlorophenyl substitution characteristic of the parent drug but exhibits altered polarity and reduced lipophilicity due to the dicarboxylic acid moieties. It arises as a specific degradation byproduct under acidic hydrolysis conditions, serving as a critical reference standard for HPLC-based impurity profiling in amlodipine bulk drug substance analysis.

On Request
Molecular Formula C17H19ClN2O5
Molecular Weight 366.8000
CAS Number 1821498-25-2 ✓ Verified
PubChem CID 19918789 ↗
Purity N/A
Product Type API Impurity
Parent Drug Amlodipine
Lead Time On Request
IUPAC Name 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid

📝 Synonyms

1821498-25-2 3-O-Desethyl-5-O-desmethyl Amlodipine 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-O-Desethyl-5-O-desmethylAmlodipine 2-((2-Aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid SK5B9F83TK SCHEMBL1610044 SCHEMBL30669880 ID153421

🔬 Chemical Identifiers

CC1=C(C(C(=C(N1)COCCN)C(=O)O)C2=CC=CC=C2Cl)C(=O)O
InChI=1S/C17H19ClN2O5/c1-9-13(16(21)22)14(10-4-2-3-5-11(10)18)15(17(23)24)12(20-9)8-25-7-6-19/h2-5,14,20H,6-8,19H2,1H3,(H,21,22)(H,23,24)
QQUGAJMOSWOMFG-UHFFFAOYSA-N

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