Diclofenac Sodium Salt is the ionized sodium derivative of diclofenac, featuring a 2-[(2,6-dichlorophenyl)amino]benzeneacetic acid core with a carboxylate group deprotonated by sodium cation. The compound retains the parent drug's chlorophenyl and acetic acid moieties but exhibits altered solubility and ionization state. Structurally, it lacks the free carboxylic acid proton, forming a zwitterionic sodium salt critical for pharmaceutical formulation stability. This impurity arises during synthetic processes involving acid-base neutralization steps. It serves as an HPLC reference standard for quantifying diclofenac-related substances in API batches.
On RequestC1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+]
InChI=1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1
KPHWPUGNDIVLNH-UHFFFAOYSA-M