Dihydralazine mesylate is a methanesulfonate salt derived from dihydralazine, characterized by a 1,2-diamino-4,5-dihydro-1H-imidazole-2-thione core substituted with two hydrazine moieties. The mesylate counterion (CH3SO3^-) forms a stable ionic bond with a protonated amine, enhancing aqueous solubility. This impurity arises from synthetic bypaths during hydralazine production, where methanesulfonic acid mediates salt formation. It functions as an HPLC reference standard for quantifying process-related impurities in parent drug formulations.
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InChI=1S/C8H10N6.CH4O3S/c9-11-7-5-3-1-2-4-6(5)8(12-10)14-13-7;1-5(2,3)4/h1-4H,9-10H2,(H,11,13)(H,12,14);1H3,(H,2,3,4)
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