ABC00543AO

Dofetilide N-Oxide

Dofetilide N-Oxide is a structurally modified analog of the parent antiarrhythmic drug Dofetilide, featuring an N-oxide substitution at the pyridine nitrogen. This oxidation introduces a polar, electron-withdrawing oxygen atom, altering the compound's hydrophilicity and hydrogen-bonding capacity while preserving the core sulfonamide and biphenyl moieties. The N-oxide functionality likely arises via oxidative degradation pathways, influencing metabolic stability and chromatographic behavior. Its distinct electronic properties make it a critical HPLC reference standard for quantifying oxidative impurities in Dofetilide formulations.

On Request
Molecular Formula C19H27N3O6S2
Molecular Weight 457.6000
CAS Number 144449-71-8 ✓ Verified
PubChem CID 101631562 ↗
Purity N/A
Product Type API Impurity
Parent Drug Dofetilide
Lead Time On Request
IUPAC Name N-[2-[4-(methanesulfonamido)phenoxy]ethyl]-2-[4-(methanesulfonamido)phenyl]-N-methylethanamine oxide
Official Reference Standards
Std Catalog # Quantity Price
USP 1225011 ↗ 25 mg USD 907.00

📝 Synonyms

144449-71-8 N-(2-(4-(methanesulfonamido)phenoxy)ethyl)-2-(4-(methanesulfonamido)phenyl)-N-methylethanamine-N-oxide N-[2-[4-(methanesulfonamido)phenoxy]ethyl]-2-[4-(methanesulfonamido)phenyl]-N-methylethanamine-N-oxide RefChem:824731 828-424-9 Dofetilide N-oxide N-[2-[4-(methanesulfonamido)phenoxy]ethyl]-2-[4-(methanesulfonamido)phenyl]-N-methylethanamine oxide N-[4-[2-[Methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]oxidoamino]ethyl]phenyl]-methanesulfonamide; N-[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]methanesulfonamide N-oxide; UK 116856; Dofetilide Impurity 4 orb1992879

🔬 Chemical Identifiers

C[N+](CCC1=CC=C(C=C1)NS(=O)(=O)C)(CCOC2=CC=C(C=C2)NS(=O)(=O)C)[O-]
InChI=1S/C19H27N3O6S2/c1-22(23,13-12-16-4-6-17(7-5-16)20-29(2,24)25)14-15-28-19-10-8-18(9-11-19)21-30(3,26)27/h4-11,20-21H,12-15H2,1-3H3
AYRPGSAYHYJPGA-UHFFFAOYSA-N

Related Products