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Dolutegravir Acid

Dolutegravir Acid is a benzylcarboxylic acid derivative featuring a 5,6-dihydro-4H-pyran-4-one core linked to a substituted phenyl ring and a cyclopropylmethylamino side chain. Its structure retains key pharmacophoric elements of dolutegravir but incorporates a terminal carboxylic acid group, likely formed via oxidative degradation of the parent drug's ester functionality. This impurity arises during synthetic pathways or storage under acidic conditions, serving as a critical HPLC reference standard for quantifying process-related degradation in API batches.

On Request
Molecular Formula C13H14N2O6
Molecular Weight 294.2600
CAS Number N/A
PubChem CID 66594300 ↗
Purity 95%
Product Type API Impurity
Parent Drug Dolutegravir
Lead Time 14 Days
IUPAC Name (4S,12aS)-3,4,6,8,12,12a-Hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H-pyrido[1?,2?:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic Acid

📝 Synonyms

1246616-73-8 DS7HC3Z5YA (4R,12aS)-3,4,6,8,12,12a-Hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H-pyrido(1',2':4,5)pyrazino(2,1-b)(1,3)oxazine-9-carboxylic acid (4R,12aS)-3,4,6,8,12,12a-Hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid RefChem:1050502 (4R,12aS)-7-Hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid (4R,12aS)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxylic acid Dolutegravir impurity F Dolutegravir Impurity 62 Dolutegravir Impurity N13

🔬 Chemical Identifiers

OC=1C(C(=CN2C[C@@H]3OCC[C@@H](N3C(C21)=O)C)C(=O)O)=O
InChI=1S/C13H14N2O6/c1-6-2-3-21-8-5-14-4-7(13(19)20)10(16)11(17)9(14)12(18)15(6)8/h4,6,8,17H,2-3,5H2,1H3,(H,19,20)/t6-,8-/m0/s1
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