Dolutegravir Enantiomer

Dolutegravir Enantiomer is the non-pharmacologically active stereoisomer of the HIV integrase inhibitor dolutegravir, characterized by the opposite configuration at the chiral center adjacent to the pyrimidin-4(3H)-one scaffold. It retains the 5-(cyclopropylmethyl)-1,3-dihydro-2H-indole-2-one core and trifluoromethyl-substituted phenyl ring but exhibits inverted spatial arrangement of substituents. This enantiomer arises as a synthetic byproduct during asymmetric synthesis and serves as a critical HPLC reference standard for enantiomeric purity analysis in API manufacturing.