Doultegravir Des fluoro impurity

Dolutegravir Des Fluoro Impurity is a structurally related pyrimidine derivative lacking a fluorine atom at the 5-position of the 2,4,5-trifluorophenyl ring present in the parent antiretroviral drug Dolutegravir. This impurity retains the 2,6-diamino-pyrimidine core and carboxamide side chain but exhibits reduced trifluoromethyl substitution, altering its electronic and steric properties. It arises as a synthetic byproduct during fluorination steps in Dolutegravir production. This compound serves as an HPLC reference standard for quantifying process-related impurities in active pharmaceutical ingredient batches.