Doultegravir Diasteriomer

Dolutegravir Diastereomer is a stereochemically distinct analog of the HIV integrase inhibitor Dolutegravir, featuring an inverted configuration at the chiral center adjacent to the pyrimidinone scaffold. Its structure incorporates a fluorinated benzyl substituent, a sodium-bound carboxylate group, and a triazole-linked naphthyridine core. The diastereomeric relationship arises from spatial arrangement differences at the C-terminus, altering intermolecular interactions while retaining key pharmacophoric elements. This compound serves as an HPLC reference standard for quantifying stereoisomeric impurities in Dolutegravir drug substance synthesis.