Doxorubicinol.TFA salt

Doxorubicinol.TFA salt is an anthracycline derivative featuring a hydroxyl group at the C-13 position, distinguishing it from its parent drug, doxorubicin, which contains an amino group at this site. The compound retains the characteristic tetracyclic aglycone core, a sugar moiety (L-daunosamine), and a methyl group at C-5. The trifluoroacetyl (TFA) salt form introduces a trifluoroacetyl functional group, enhancing solubility and stability. This impurity arises via hydrolytic degradation of doxorubicin during synthesis or storage, representing a critical quality attribute in API manufacturing. It serves as a reference standard for HPLC-based impurity profiling in doxorubicin-containing pharmaceuticals.