ABC00609ST

Empagliflozin open ring impurity

Empagliflozin open ring impurity arises from hydrolytic cleavage of the parent drug's pyran ring, yielding a linear structure with a chloromethyl substituent, a vicinal diol moiety, and a carboxylic acid ester. The compound retains the aromatic core but exhibits altered stereochemistry at the C-6 position. This impurity functions as an HPLC reference standard for quantifying degradation pathways in empagliflozin synthesis and stability studies.

On Request
Molecular Formula C23H29ClO8
Molecular Weight 468.9000
CAS Number 1620758-34-0 ✓ Verified
PubChem CID 102362500 ↗
Purity N/A
Product Type API Impurity
Parent Drug Empagliflozin
Lead Time On Request
IUPAC Name (1R,2S,3R,4R,5R)-1-[4-chloro-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]hexane-1,2,3,4,5,6-hexol

📝 Synonyms

1620758-34-0 (1R,2S,3R,4R,5R)-1-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)hexane-1,2,3,4,5,6-hexaol XRZ9SK8LLM (1R,2S,3R,4R,5R)-1-[4-chloro-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]hexane-1,2,3,4,5,6-hexol (1R)-1-C-(4-Chloro-3-((4-(((3S)-tetrahydro-3-furanyl)oxy)phenyl)methyl)phenyl)-D-glucitol D-Glucitol, 1-C-(4-chloro-3-((4-(((3S)-tetrahydro-3-furanyl)oxy)phenyl)methyl)phenyl)-, (1R)- (1R)-1,5-Dihydroxyempagliflozin UNII-XRZ9SK8LLM Empagliflozin Impurity 15 C23H29ClO8

🔬 Chemical Identifiers

C1COC[C@H]1OC2=CC=C(C=C2)CC3=C(C=CC(=C3)[C@H]([C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)O)Cl
InChI=1S/C23H29ClO8/c24-18-6-3-14(20(27)22(29)23(30)21(28)19(26)11-25)10-15(18)9-13-1-4-16(5-2-13)32-17-7-8-31-12-17/h1-6,10,17,19-23,25-30H,7-9,11-12H2/t17-,19+,20+,21+,22-,23-/m0/s1
RKDDAJYLEWTGMU-PNZPLEPNSA-N

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