Enalaprilat dihydrat

Enalaprilat dihydrate is a hydrated derivative of the angiotensin-converting enzyme inhibitor enalaprilat, featuring a pentanoic acid chain linked to a tetrazole moiety via an α-amino group. The dihydrate form incorporates two crystallization water molecules, influencing its solubility and stability profile. Structurally, it retains the parent compound’s core pharmacophore but exhibits distinct hygroscopic properties due to hydrogen-bonding interactions with water. This impurity arises during synthetic processes or degradation pathways involving enalaprilat. It serves as a critical reference standard for HPLC-based impurity profiling in enalaprilat-containing pharmaceuticals.