ezetimibe amide des alcholol

Ezetimibe amide des alcholol is a structurally related impurity derived from the parent drug ezetimibe through the replacement of the phenolic hydroxyl group with an amide moiety, resulting in a tetrahydrofuran-based scaffold with altered hydrogen bonding capacity. This compound retains the core 4-(4-chlorophenyl)-6-isopropyl-2-pyrimidinylamine framework but features a deoxygenated alcohol functionality, leading to distinct chromatographic and spectroscopic properties. It arises as a synthetic byproduct during API manufacturing via amidation pathways. This compound serves as an HPLC reference standard for quantifying process-related impurities in ezetimibe formulations.