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ezetimibe des fluoro

Ezetimibe des fluoro is a structural analog of ezetimibe, featuring a 4-chlorophenyl-substituted piperazine ring linked to a 3-(4-hydroxyphenyl)propanol moiety, with a defluorinated aromatic substituent at the 4-position of the benzoyl group. This impurity arises from incomplete fluorination during synthetic processes, retaining a meta-hydroxybenzoyl piperazine core. It serves as a critical HPLC reference standard for quantifying desfluoro-related impurities in ezetimibe drug substances.

On Request
Molecular Formula C24H22FNO3
Molecular Weight 391.4000
CAS Number 302781-98-2 ✓ Verified
PubChem CID 58827445 ↗
Purity N/A
Product Type API Impurity
Parent Drug Ezetimibe
Lead Time On Request
IUPAC Name (3R,4S)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-1-phenylazetidin-2-one
Official Reference Standards
Std Catalog # Quantity Price
USP 1A07330 ↗ 25 mg USD 1650.00

📝 Synonyms

(3R,4S)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-1-phenylazetidin-2-one DTXSID00730350 (3R,4S)-3-((3S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)-1-phenylazetidin-2-one RefChem:401078 DTXCID40681094 898-579-5 Desfluoro Ezetimibe 302781-98-2 Desfluoro-ezetimibe (3R,4S)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)-1-phenylazetidin-2-one

🔬 Chemical Identifiers

C1=CC=C(C=C1)N2[C@@H]([C@H](C2=O)CC[C@@H](C3=CC=C(C=C3)F)O)C4=CC=C(C=C4)O
InChI=1S/C24H22FNO3/c25-18-10-6-16(7-11-18)22(28)15-14-21-23(17-8-12-20(27)13-9-17)26(24(21)29)19-4-2-1-3-5-19/h1-13,21-23,27-28H,14-15H2/t21-,22+,23-/m1/s1
YWZUFJFIXFJKBD-XPWALMASSA-N

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