ABC00687ID

Famotidine sulfoxide

Famotidine sulfoxide is a structurally related oxidation derivative of famotidine, characterized by the sulfoxide functional group (S=O) formed via oxidation of the thiazole ring's sulfur atom. The compound retains the core 4-(4-amidinophenyl)-2-(5-ethyl-1H-imidazol-2-yl)thiazole scaffold, with the thiazole S-atom substituted as a sulfoxide (R-S(O)-R'). This impurity arises during oxidative degradation pathways or synthetic over-oxidation processes. It serves as a critical HPLC reference standard for quantifying oxidation-related impurities in famotidine drug substance and product stability studies.

On Request
Molecular Formula C8H15N7O3S3
Molecular Weight 353.5000
CAS Number 90237-03-09
PubChem CID 13949559 ↗
Purity N/A
Product Type API Impurity
Parent Drug Famotidine
Lead Time On Request
IUPAC Name 3-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfinyl]-N'-sulfamoylpropanimidamide

📝 Synonyms

Famotidine sulfoxide 90237-03-9 Famotidine S-oxide KGG3Y4C7RV Propanimidamide, 3-(((2-((aminoiminomethyl)amino)-4-thiazolyl)methyl)sulfinyl)-N-(aminosulfonyl)- RefChem:200914 3-[2-(Diaminomethyleneamino)-1,3-thiazol-4-ylmethylsulphinyl]-N-sulphamoylpropanamidine UNII-KGG3Y4C7RV 3-(((2-Guanidinothiazol-4-yl)methyl)sulfinyl)-N-sulfamoylpropanimidamide CHEMBL901

🔬 Chemical Identifiers

C1=C(N=C(S1)N=C(N)N)CS(=O)CC/C(=N/S(=O)(=O)N)/N
InChI=1S/C8H15N7O3S3/c9-6(15-21(12,17)18)1-2-20(16)4-5-3-19-8(13-5)14-7(10)11/h3H,1-2,4H2,(H2,9,15)(H2,12,17,18)(H4,10,11,13,14)
LAZSSGBZNCVJCB-UHFFFAOYSA-N

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