Fenofibric acid Acyl- B-D glucuronide

Fenofibric acid Acyl-β-D-glucuronide is a hepatically derived conjugate formed via glucuronidation of fenofibric acid, featuring an acyl-ester linkage between the parent drug's carboxylic acid moiety and the C-6 hydroxyl of β-D-glucuronic acid. The structure incorporates a 4-chlorophenyl ring, an isopropyl-substituted methylene bridge, and a six-membered glucopyranose ring with a terminal carboxylic acid. This metabolite arises as a major hepatic conjugate, exhibiting enhanced water solubility due to the glucuronic acid moiety. It serves as an HPLC reference standard for quantitative impurity profiling in fenofibric acid drug substance analysis.