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Folic acid Impurity F

Folic acid Impurity F (CAS 1391194-56-1) is a chlorinated pteridine derivative featuring a 4-amino-6-hydroxy-5-chloropyrimidine ring fused to a pyrazine moiety, linked to a para-chlorobenzoyl group via a methylene bridge. The structure incorporates a chloro substituent at the 5-position of the pyrimidine core, replacing a hydrogen atom present in the parent folic acid. This impurity arises via oxidative chlorination during synthetic processes, introducing a stable aromatic chloro functionality that disrupts the glutamate conjugation site. It serves as a critical HPLC reference standard for quantifying process-related impurities in folic acid formulations.

On Request
Molecular Formula C7H6ClN5O
Molecular Weight 211.6100
CAS Number 1391194-56-1 ✓ Verified
PubChem CID 136070711 ↗
Purity N/A
Product Type API Impurity
Parent Drug Folic acid
Lead Time On Request
IUPAC Name 2-amino-7-(chloromethyl)-3H-pteridin-4-one

📝 Synonyms

1391194-56-1 Folic Acid EP Impurity F 2-Amino-7-(chloromethyl)pteridin-4(1H)-one 2-Amino-7-(chloromethyl)-3H-pteridin-4-one 2-Amino-7-(chloromethyl)pteridin-4(1H)-one (90%) 2-Amino-7-(chloromethyl)pteridin-4(1H)-one Hydrochloride 2-amino-7-(chloromethyl)-3,4-dihydropteridin-4-one 2-Amino-7-(chloromethyl)pteridin-4(1H)-one; 4(3H)-Pteridinone, 2-amino-7-(chloromethyl)-; 2-Amino-7-(chloromethyl)-4(3H)-pteridinone Folic acid impurity F AR3Q4F7XTA

🔬 Chemical Identifiers

C1=C(N=C2C(=N1)C(=O)NC(=N2)N)CCl
InChI=1S/C7H6ClN5O/c8-1-3-2-10-4-5(11-3)12-7(9)13-6(4)14/h2H,1H2,(H3,9,11,12,13,14)
WHPPYWZHBUBHST-UHFFFAOYSA-N

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