Fosfomycin trometamol impurity c

Fosfomycin trometamol impurity C is a phosphonic acid ester derivative containing a tertiary amine group from trometamol (2-amino-2-hydroxymethyl-1,3-propanediol). It features a phosphonate moiety linked via an ether bond to the hydroxyl group of the parent fosfomycin scaffold. This impurity arises as a synthetic byproduct during API manufacturing, specifically during pH adjustment steps involving trometamol as a buffering agent. Its distinct amine-phosphonate linkage differentiates it from fosfomycin’s native structure. This compound serves as an HPLC reference standard for impurity profiling in fosfomycin-based pharmaceuticals.