ABC00746PF

Hydrocortisone 9beta,11beta-Epoxide

Hydrocortisone 9beta,11beta-Epoxide is a steroid-derived impurity formed via oxidative epoxidation of the parent hydrocortisone molecule at the 9,11-positions, introducing a transannular ether bridge between adjacent beta-oriented hydroxyl groups. This epoxide moiety alters the steroid's conformational flexibility and reactivity, serving as a critical HPLC reference standard for quantifying oxidative degradation pathways in hydrocortisone-based pharmaceuticals.

On Request
Molecular Formula C21H28O5
Molecular Weight 360.4000
CAS Number 10072-97-6 ✓ Verified
PubChem CID 112075 ↗
Purity N/A
Product Type API Impurity
Parent Drug Hydrocortisone
Lead Time On Request
IUPAC Name (1S,2S,10S,11S,14R,15S,17S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyl-18-oxapentacyclo[8.8.0.01,17.02,7.011,15]octadec-6-en-5-one

📝 Synonyms

RefChem:868433 Pregn-4-ene-3,20-dione, 9,11-epoxy-17,21-dihydroxy-, (9beta,11beta)- 10072-97-6 Hydrocortisone (9b,11b)-Epoxide 9beta,11beta-Epoxy-17,21-dihydroxypregn-4-ene-3,20-dione Hydrocortisone (9beta,11beta)-Epoxide (1S,2S,10S,11S,14R,15S,17S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyl-18-oxapentacyclo[8.8.0.01,17.02,7.011,15]octadec-6-en-5-one Pregn-4-ene-3,20-dione, 9,11-epoxy-17,21-dihydroxy-, (9beta,11beta)- (9CI) 9(11)-Epoxide Hydrocortisone 17,21-Dihydroxy-9?,11?-epoxypregn-4-ene-3,20-dione (9?,11?-Epoxyhydrocortisone)

🔬 Chemical Identifiers

C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@]24[C@@H](O4)C[C@]5([C@H]3CC[C@@]5(C(=O)CO)O)C
InChI=1S/C21H28O5/c1-18-7-5-13(23)9-12(18)3-4-15-14-6-8-20(25,16(24)11-22)19(14,2)10-17-21(15,18)26-17/h9,14-15,17,22,25H,3-8,10-11H2,1-2H3/t14-,15-,17-,18-,19-,20-,21+/m0/s1
FJCQSIDXADHVFH-FEUSSREZSA-N

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