Hydroxy Chloroquine

Hydroxy Chloroquine is a 4-aminoquinoline derivative featuring a hydroxyl substitution at the 4-position of the butyl side chain, distinguishing it from the parent Chloroquine. Its structure includes a 7-chloroquinoline ring system linked to a diethylamino group via a hydroxyl-terminated butylene bridge. This compound arises as a synthetic byproduct during Chloroquine production due to competing hydroxylation pathways. The hydroxyl group introduces steric and electronic modifications, altering solubility and metabolic profiles. Analytically, it serves as a reference standard for HPLC-based impurity profiling in Chloroquine APIs.