ABC00758VD

Imatinib Impurity B

Imatinib Impurity B is a demethylated analog of the parent drug, arising from incomplete alkylation during synthesis. It retains the pyrimidine-2-ylmethylamine core and piperazine linkage but lacks the N-methyl substitution on the aniline moiety, replacing it with a hydrogen. This structural deviation introduces distinct chromatographic and spectroscopic properties, critical for differentiation during analytical profiling. The compound serves as a reference standard for HPLC-based quantification of process-related impurities in Imatinib API batches.

On Request
Molecular Formula C21H28N6O
Molecular Weight 380.5000
CAS Number 581076-65-5 ✓ Verified
PubChem CID 29980915 ↗
Purity N/A
Product Type API Impurity
Parent Drug Imatinib
Lead Time On Request
IUPAC Name N-[3-(diaminomethylideneamino)-4-methylphenyl]-4-[(4-methylpiperazin-1-yl)methyl]benzamide

📝 Synonyms

581076-65-5 GU9XYG8THC N-[3-[(Aminoiminomethyl)amino]-4-methylphenyl]-4-[(4-methyl-1-piperazinyl)methyl]benzamide DTXSID901121965 N-(3-((Aminoiminomethyl)amino)-4-methylphenyl)-4-((4-methyl-1-piperazinyl)methyl)benzamide RefChem:1091126 DTXCID001553513 N-(3-GUANIDINO-4-METHYLPHENYL)-4-(METHYLPIPERAZINE-1-YL-METHYL)BENZAMIDE Imatinib EP Impurity B N-[2-Methyl-5-[[4-[(4-methylpiperazin-1-yl)methyl]benzoyl]amino]phenyl]guanidine

🔬 Chemical Identifiers

CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)N=C(N)N
InChI=1S/C21H28N6O/c1-15-3-8-18(13-19(15)25-21(22)23)24-20(28)17-6-4-16(5-7-17)14-27-11-9-26(2)10-12-27/h3-8,13H,9-12,14H2,1-2H3,(H,24,28)(H4,22,23,25)
AJNIAMJOBVYWFM-UHFFFAOYSA-N

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