Imatinib Impurity C

Imatinib Impurity C is a 4-demethyl derivative of the parent drug's pyridine ring, retaining the benzamide and piperazine core. Its structure features a pyridine-2-ylmethylamine moiety linked to a 4-amidinophenyl group, lacking the methyl substitution at the 4-position. This impurity arises during synthetic pathways involving N-methylation steps. It serves as an HPLC reference standard for quantifying 4-demethylated byproducts in imatinib formulations.